QVAR® Gets More Medicine Where It Needs to Go3
- QVAR is the first and only small particle ICS indicated for patients as young as 5 years of age6
- QVAR outdistances fluticasone in improving lung function4
- QVAR delivers up to 58% lung deposition*5,10
- QVAR is a prodrug. That means the inactive drug deposited in the mouth and oropharynx is swallowed before activation can occur. As a result, QVAR is associated with a very low incidence of oropharyngeal side effects8,9
- QVAR’s extra-fine particles, just 1.1 microns1 treat inflammation in even the smallest airways where more than half of asthma-related airway resistance takes place2
- QVAR can be used with or without a spacer6
QVAR: a small-particle ICS, designed to reach inflammation in even the smallest airways3
Your Asthma Patients Can Start on Q and Stay on Q ―
Because QVAR Goes the Distance.
References:
- Martin RJ. Therapeutic significance of distal airway inflammation in asthma. J Allergy Clin Immunol. 2002;109(2):S447-S460.
- Yanai M, Sekizawa K, Ohrui T, et al. Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure. J Appl Physiol. 1992;72:1016-1023.
- Leach CL, Davidson PJ, Hasselquist BE, Boudreau RJ. Lung deposition of hydrofluoroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone*: a cross-over study in healthy volunteers. Chest. 2002;122:510-516.
- Thongngarm T, Silkoff PE, Kossack WS, Nelson HS. Hydrofluoroalkane-134A beclomethasone or chlorofluorocarbon fluticasone: effect on small airways in poorly controlled asthma. J Asthma. 2005;42:257-263.
- Leach C. Effect of formulation parameters on hydrofluoroalkane-beclomethasone dipropionate drug deposition in humans. J Allergy Clin Immunol. 1999;104:S250–S252.
- QVAR Prescribing Information, IVAX Laboratories Inc., 2008.
- IMS Health National Prescription Audit, Total Rx Data. February 2009.
- Thompson PJ, Davies RJ, Young WF, et al. Safety of hydrofluoroalkane-134abeclomethasone dipropionate extrafine aerosol. Respir Med. 1998;92(SupplA):33-39
- Winkler J, Hochhaus G, Derendorf H. How the lung handles drugs: pharmacokinetics and pharamacodynamics of inhaler corticosteroids. Proc Am Thor Soc. 2004; 1:356-363.
- Roller CM, Zhang G, Troedson RG, et al. Spacer inhalation technique and deposition of extrafine aerosol in asthmatic children. Eur Respir J. 2007;29(2):299-306
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